09 Efficacy of sulfadoxine.pmd
نویسندگان
چکیده
1New Halfa Hospital, New Halfa, Sudan. 2Faculty of Medicine, University of Khartoum, Khartoum, Sudan. Received: 24/06/03; accepted: 29/09/03 ABSTRACT A prospective clinical trial was carried out to determine in vivo efficacy of sulfadoxine/pyrimethamine for the treatment of uncomplicated Plasmodium falciparum malaria in children in New Halfa. Forty patients were enrolled; 31 completed the 28-day follow-up. Six (19.4%) patients showed recurrence of parasitaemia during follow-up, while the rest (80.6%) cleared the parasites and responded fully to treatment. All the failures were late treatment failures. Parasite genotyping showed that 1 (16.7%) of the 6 cases of late parasitaemia was due to reinfection while the rest (83.4%) were due to true recrudescence. During the follow-up period 22.6% of patients showed gametocytaemia. The high level of treatment failure as well as gametocytaemia necessitates the introduction of artesunate in this area in combination therapy.
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